The Uruguayan international has endured an up and down spell on the South Coast following his arrival from Bologna last year, and is thought to be ready to move on.
Despite a slightly underwhelming period in England, Ramirez’s reputation in Italy has remained high.
This has alerted Inter and Fiorentina, who are ready to launch moves to offer him a route back to Serie A.
Mauricio Pochettino does not see the South American as a first-team regular as it stands, and may sanction his sale in order to raise funds to draft in players more suited to his system in the New Year.
Ramirez himself is also open to a switch, with regular action ahead of the 2014 World Cup high on his list of priorities.
Turkish giants Galatasaray are also watching the playmaker, with new manager Roberto Mancini keen to bring in new players in winter.
Ramirez was linked with a move to Liverpool prior to joining Southampton in a £12m deal.
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