The Old Lady recently snapped up the Argentine from Napoli in a deal worth close to £80m, which prompted the Naples side to move for Arkadiusz Milik of Ajax.
And the next forward that could be set for a switch is Mandzukic, who is reportedly wanted by Everton, West Ham and Spurs.
The Hammers are known to be searching for attacking additions, and could look to follow their seemingly imminent Jonathan Calleri deal with the 30-year-old.
Everton meanwhile may be on the lookout for a Romelu Lukaku replacement before long with the Belgian a Chelsea target.
Spurs’ interest appears to be the most unlikely, with Vincent Janssen having been signed from AZ Alkmaar of late to support Harry Kane.