The Argentine signed for the Lilywhites back in 2014, but despite arriving from Sevilla with a reputation as a solid defender in La Liga, the now 29-year-old has failed to make any sort of impact in north London.
This has led to speculation that Mauricio Pochettino is ready to axe him before the close of the transfer window, but a proposed move to Espanyol fell through when the Barcelona-based side refused to match their valuation.
However, reports claim that Roma are now keen.
The Italians are believed to be on the lookout for a new centre-back and are exploring the possibility of a loan deal with a view to a permanent transfer next year.
Spurs are likely to be keen to offload the South American, who was shipped back out to Sevilla on loan for the end of last season following the arrival of Kevin Wimmer.