Mauricio Pochettino has adapted his Tottenham line-up in recent weeks to deal with a growing list of injuries to his side.
The loss of Chrisitan Eriksen, Serge Aurier and Jan Vertonghen saw Pochettino call on a three-man back line in the weekend’s win over Huddersfield.
Before that, Spurs had rolled out a 4-2-3-1 with a very attacking front line featuring all their big-hitters.
Playing four-at-the-back, however, failed to stop Inter Milan from coming from behind to snatch all three points at the San Siro in the opening game of this season’s Champions League.
For the visit of Barcelona to Wembley, Spurs will again be without Eriksen as the Danish creative-midfielder continues his recovery from a stomach injury.
But a majority of Tottenham Hotspur fans still believe Pochettino should rely on a four-man defence, as revealed in our poll.
Two-thirds of supporters feel a back line consisting of two, rather than three, centre-backs will be able to handle Barcelona’s world-class attackers far better than a make-shift trio with Vertonghen absent.
With Eriksen expected to be ruled out with injury, his place in the side is available for Erik Lamela to fill. But should Harry Kane start up front as the sole striker, or should he be rested on Wednesday night?