This article is part of Football FanCast's Opinion series, which provides analysis, insight and opinion on any issue within the beautiful game, from Paul Pogba's haircuts to League Two relegation battles...

Jose Mourinho has been appointed as Tottenham Hotspur’s manager and one has to imagine that not everyone will be happy about it.

Mauricio Pochettino had built up some credit in the bank - spending over five years at the club and overseeing two Premier League title challenges and a run to the Champions League final - while also forging relationships with his players.

Now, though, all has changed. Some Spurs players only know of a time when Pochettino was manager but Mourinho will bring with him new ideas and a new way of doing things.

And that could mean some hard truths for a few players in the squad.

Football FanCast takes a look at the major losers from the appointment.

Hugo Lloris

Already out injured, Mourinho will have to play Paulo Gazzaniga from the outset, purely due to his availability, meaning Hugo Lloris faces an uphill battle to reclaim his spot.

More pertinently, Mourinho could well decide to strip the Frenchman of his captaincy to stamp his own mark on this Spurs team, especially as he won't be back on the pitch for a while yet.

No armband depletes Lloris' relevance to this side as it seemed to protect him from getting dropped after a howler against Southampton earlier this season.

Harry Winks

Mourinho has often preferred to have genuinely powerful midfield players in the centre of the pitch - think Michael Essien and Nemanja Matic - and Winks is not that.

He is lithe and skillful, instead of being the tough-tackling presence that Mourinho often prefers. That is offered by the likes of Tanguy Ndombele, Eric Dier, Victor Wanyama and Moussa Sissoko.

It is likely that the England international will lose his spot in the short-term and could well face a significant battle to get back into the team.

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Giovani Lo Celso

Joined the club in the summer from Real Betis on an initial loan deal and now has to prove his worth all over again.

If Mourinho takes a liking to him, that deal could well be made permanent, but if not, he will surely be shipped straight back to Spain.

Add in that he reportedly joined the club because of his desire to work with Pochettino, per Sky Sports via the Daily Express, and one has to feel that he could be a major loser.

It's never easy for recent signings when the manager who brought them in is suddenly axed.

Ryan Sessegnon

Sessegnon is in a similar boat to Lo Celso.

He moved to the club in the summer and could have been set for a stint in the first-team under Pochettino, who has a solid track record of developing young players - ranging from Luke Shaw to Harry Kane.

With Son Heung-Min already in front of him in the pecking order at left wing, the former Fulham ace has serious work to do to prove his worth to Mourinho.

There are very few instances throughout the Portuguese's career in which he's successfully improved results by giving chances to young players.

Versatility may help but Sessegnon doesn't seem like Mourinho's type of defender - his last title win had Cesar Azpilicueta at left-back - and he could end up with splinters from his time on the bench.