Tottenham Hotspur kick off their season with a home clash against Aston Villa on Saturday.
It is the first time that Spurs have played at home in their opening game since the 2010-11 season and they could also debut two of their new signings versus the newly-promoted outfit.
There are a number of injury issues, however.
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That leaves a shortage of options in certain positions but Mauricio Pochettino still has a strong squad available to him.
Hugo Lloris did not enjoy an excellent pre-season due to injury but he is fit and should play in goal.
The summer departure of Kieran Trippier and Juan Foyth’s injury means Kyle Walker-Peters is likely to play at right-back, particularly with Serge Aurier missing out on pre-season.
The lack of options at left-back means that Danny Rose, who almost left the club in the summer, is likely to be granted a reprieve, though Pochettino could shift Vertonghen from centre-back to left-back. Toby Alderweireld is fit and should play.
The midfield is intriguing and Lo Celso is unlikely to be thrust in at the deep end.
Thus, playing Harry Winks in defensive midfield with Ndombele and Moussa Sissoko in central midfield makes sense.
That would allow Christian Eriksen the chance to play as a No.10 after he failed to secure a move away in the English transfer window.
There is a lack of width here, but partnering Lucas Moura with the ever-reliable Harry Kane would alleviate that problem somewhat and allow for some fluidity.
Lo Celso, as mentioned, is more likely to be an option off the bench, along with Erik Lamela, who has enjoyed an excellent pre-season, and young striker Troy Parrott.