The England international has struggled to force his way into contention in Premier League fixtures for Spurs despite starting in the Europa League.
Defoe is thought to be keen to fight for his place, but Daniel Levy is expected to back Andre Villas Boas in January, despite letting his boss spend to the tune of £100 million this summer and this could leave the 31 year old surplus to requirements.
Porto striker Jackson Martinez is thought to be top of the list for the Lilywhites as they look set to raid the January sales for offensive talent.
AVB is thought to have told his bosses at White Hart Lane that goalscoring has been a crucial problem this season and that targeting a new centre forward in January is essential.
The former West Ham striker, Defoe, is thought to have a whole queue of clubs wanting to snap Defoe up, especially in the MLS.
Newcastle were also believed to have been readying a £6 million bid for Jermain Defoe last August, although reports suggest they have now cooled this interest.
Tottenham entertain Newcastle at White Hart Lane weekend, following a goalless draw with Everton at Goodison Park on Sunday.