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Loads of Tottenham fans have been reacting to yet another injury setback, as Danny Rose, Eric Dier and Victor Wanyama have all joined Jan Vertonghen on the treatment table.

Tottenham travel to Wolves on Saturday evening in what is sure to be a very difficult encounter.

The newly promoted side were comfortably beaten by Watford in their last home match, but they have already proven they can take on the big boys at Molineux with a 1-1 draw against Manchester City.

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Spurs will have to go there without several first team players, as Mauricio Pochettino has confirmed Rose, Wanyama and Dier will not feature.

The trio are suffering from groin, knee and thigh problems respectively, and are not expected to return before the next international break.

Pochettino is already without Vertonghen after he injured his hamstring last month, and the defensive ranks are suddenly looking extremely thin.

Loads of fans have been giving their verdict on this latest setback, and you can find some of the best Twitter reactions down below…