Spurs were linked with a move for the Bosnian international over the summer, but were unable to tie up a double deal involving Erik Lamela.
The Argentine made the switch to White Hart Lane, and now the Londoners are ready to swoop for his former team-mate.
The 23-year-old has been in fine form for Roma this term, helping them to the top of the Serie A table.
But, with his contract set to expire at the end of next season he could be allowed to leave the Italian capital this winter.
Tottenham are pondering a £20m move for the playmaker, who has been on their radar for some time.
Andre Villas-Boas is keen to further bolster his squad in January, despite spending over £100m during the last window.
Spurs have the financial muscle to invest once again, and Pjanic is near the top of wish list.
The ex-Lyon man is thought of as one of Italian football’s top creative players and has developed a reputation as a set-piece expert.
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