Spurs have been tracking the Bosnian international for some time, and are believed to have made him their top target as the transfer window draws to a close.
The London club’s new director of football Franco Baldini – who arrived at White Hart Lane from the Stadio Olimpico – is believed to have made contact with his successor regarding the availability of the £15m-rated midfielder
Roma are keen to hold onto the 23-year-old, but are aware that another season without European football in the Italian capital may make it difficult to convince him to stay.
Tottenham are hopeful that a change of scenery could appeal to Pjanic, who would add greater creativity to their engine room.
The classy midfielder only arrived in Rome two years ago from Lyon, where he forged a reputation as one of the continent’s top young talents.
His career has stagnated a little in Italy, but he has still managed to take his international cap tally to 40.
A deal may hinge on the outcome of Gareth Bale’s proposed move to Real Madrid, with the potential cash injection likely to be used by Andre Villas-Boas to strengthen his squad.
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