The 25-year-old was part of Inter’s Champions League winning 2009/10 squad and returned to the San Siro in January 2015 following three-and-a-half seasons at Newcastle United.
West Ham are prowling the transfer market for an emergency left-back following an injury to resident No.3 Aaron Cresswell, which could see him sidelined for the next four months.
That has resulted in a succession of bids for Norwich City defender Martin Olsson, but it appears the Hammers have now turned their attentions to the Italy international.
Santon has reportedly flown to England to hold talks with West Ham and undergo a medical at the Olympic Stadium.
The Irons are expected to agree a loan deal for the full-back with the view to a permanent £5million transfer next summer.