Lilywhites boss Antonio Conte is tasked with sparking a reaction from his side after they put in a woeful display against arch-rivals Arsenal at the weekend, a game in which they were outfought and outplayed for the most part.
It also poses a big decision on whether to stick or twist with his starting lineup as mistakes against the defending champions will almost certainly be punished.
Several of his key players have returned from injury and Spurs do hold a very impressive record against the Citizens in recent times, so it’ll be interesting to see what sort of XI he deploys.
Here’s what we are predicting…
There could be as many as four changes to the side that tasted defeat to the Gunners, starting with the long-awaited return of Rodrigo Bentancur.
Missing since his World Cup exploits, the Uruguayan’s absence has been a frustrating one for the team but Conte revealed in his pre-game press conference that he would be available for selection at long last. Given the importance of a result, he should start alongside Pierre-Emile Hojbjerg.
Despite an error that gifted Arsenal their opener, skipper Hugo Lloris will remain between the sticks but we could see the “reliable” Ben Davies return to the back three, replacing Clement Lenglet on the left-hand side. Meanwhile, out wide, there could be a further two changes with Emerson Royal and Ivan Perisic returning to the starting XI.
Further up the pitch, Conte is likely to keep the faith with Heung-min Son despite his ongoing form struggles, along with Harry Kane, who must improve in front of goal if he’s to find the net against Pep Guardiola’s men.
Dejan Kulusevski should also retain his place after returning from injury last time out, though Bryan Gil is pushing for another start after impressive in what little opportunity he had in the Swede’s absence.