Nuno Santo could be without two members of his first-team squad after the international break, according to reports...

What's the latest?

The Daily Mail claim that Argentina duo Giovani Lo Celso and Cristian Romero are facing over three weeks out of action after it emerged that they were under investigation for breaching Brazil's quarantine rules.

It's thought that the Spurs pair are facing 14 days of quarantine in Brazil following their World Cup qualifying clash before another ten days upon their return to the United Kingdom.

They have been accused of failing to declare on official documents that they had travelled from the UK when they arrived in Sao Paolo on Friday.

This would, in turn, rule them out of at least three Premier League matches, one Carabao Cup clash and one UEFA Europa Conference League group game, too.

Hammer blow

After the start Spurs have had to the new season, this latest development should leave Nuno absolutely furious as he'll be without two key squad members for some very crucial encounters.

These fixtures include games against arch-rivals Arsenal and Chelsea, and a trip to Rennes, where they will undoubtedly want to start well to try and win that inaugural competition.

Neither player has featured for many minutes so far this season but given the congested calendar in September, they would have been handed plenty of opportunities to get game time.

The Portuguese head coach was even against the duo travelling abroad during this international break, so for them to get caught up in a saga will only leave him more angry.

"Yes, it’s a big problem, not only for our players, it’s a problem for all the South American players playing in the Premier League because they have to obey the government laws," he revealed to reporters, via talkSPORT. "But we must be aware that saying no to our national team is very difficult. It’s very difficult, so we’ll see how things go."

He later added: "It [is] clear – as a club we don’t approve of the situation. What we want is a solution for everybody because this will be a big problem."

Nuno may well struggle to keep up Spurs' 100% in the top-flight and continue their fine form into other competitions without having the full depth of his squad available to him.

This will surely come as a hammer blow heading into Saturday's clash with Crystal Palace.

AND in other news, Nuno can fix alarming Spurs issue by unleashing "phenomenal" £100k-p/w gem in new role...