Tottenham Hotspur are gearing up to open the return of Premier League football. The domestic clubs have cast a watchful eye over their players during the international break and will be looking to vie for three points in their respective league fixtures.

Second place Spurs will play host to out of favour Manchester City, who are in desperate need of a win in order to climb the table. However, Jose Mourinho is unbeaten in his last seven matches and will see this evening's clash as a huge opportunity to make moves in what could be a potential title race.

The north Londoners are currently harbouring six first team injuries, including the recent loss of Tanguy Ndombele. With this in mind, here's how Football FanCast has predicted Mourinho to line up tonight...

Usual attacking midfield choice Ndombele has picked up a foot injury and won't be available for selection. Giovani Lo Celso will likely come in to replace the France international in what could be a huge match for him to prove himself to Mourinho.

In a more bold prediction, the manager may opt to deploy Moussa Sissoko on the right-hand side in order to rest Gareth Bale and play a more tactical approach. The Frenchman plays on the wing for his country and has shown he can put his speed and strength to good use out wide. It will certainly be an option City won't expect and Sissoko's strong attacking-defensive balance will help nullify the threat posed by Raheem Sterling.

With space in the midfield, £50,000-a-week man Harry Winks could return to give Pierre-Emile Hojbjerg a helping hand in protecting the backline against Pep Guardiola's attack. City will be hungry for the win and will undoubtedly throw everything at trying to unsettle Spurs.

Across the backline, everything stays the same apart from the absence of new signing Matt Doherty, who is currently self-isolating. Natural back up Serge Aurier will likely be the man to fill the spot after falling down the pecking order since the former Wolves man arrived.

In other news, Dele Alli situation could brew storm between Daniel Levy & Jose Mourinho...