Tottenham Hotspur boss Nuno Santo is facing plenty of selection decisions heading into his side's return to Premier League action this afternoon.

The north London outfit head to the northeast to face Newcastle United at St James' Park but preparation has been far from ideal this week.

Spurs' quartet of South Americans only returned to the club yesterday, whilst reports suggest that two first-team players have tested positive for the ongoing pandemic, meaning they'll miss this encounter.

It certainly hands the Portuguese head coach a massive headache ahead of kickoff but what sort of lineup could we see today? Here's what we are predicting...

There could be just one change from the side that defeated Aston Villa last time out.

With four players featuring in South America before returning to N17 only yesterday, it would be a surprise to see many feature. As a result, Cristian Romero, who has dealt with his fair share of injury problems since the summer, is not risked and the spot is handed to Joe Rodon instead.

However, Brazil right-back Emerson Royal makes the starting XI and they are joined by Sergio Reguilon and Eric Dier, in front of club captain Hugo Lloris.

It means that Nuno's engine room is unscathed, so Pierre-Emile Hojbjerg and Oliver Skipp feature alongside Tanguy Ndombele.

Heung-min Son emerged as a doubt but according to reports in his home country, South Korea, he is expected to feature, with the £18m-rated Lucas Moura, who Dier once dubbed a "nightmare" to train against, getting the nod over Steven Bergwijn and Bryan Gil.

Meanwhile, upfront, Nuno keeps the faith with Harry Kane despite his lack of goals in the Premier League. He is yet to score in his five starts.

It means there is no place for the likes of Dele Alli, Davinson Sanchez, Giovani Lo Celso or Bryan Gil.

AND in other news, Spurs' £27m-rated "big talent" can spoil Newcastle's takeover party at St James' Park...