Nuno Santo is dealing with further injury woes as his Tottenham Hotspur side look to bounce back against Chelsea in the Premier League this afternoon.

The north London outfit have endured a tough week, seeing their unbeaten record in the top-flight come to an end at the hands of then-winless Crystal Palace before they had to settle for a point against Rennes in the UEFA Europa Conference League.

Now they face the small matter of the Champions of Europe at the Tottenham Hotspur Stadium in a bid to get back on track.

But what sort of XI could we see from the Portuguese head coach? Here's what we are predicting...

Predicted-Spurs-XI-vs-Chelsea-in-the-Premier-League

Nuno has been without the services of no fewer than six first-team players this week and on Thursday, their mounting problems got worse as both Steven Bergwijn and Lucas Moura picked up knocks - neither could feature here.

Eric Dier is also likely to still be on the treatment table.

However, it's expected that Heung-min Son will be able to make a much-needed return after picking up an issue during the international break, whilst the South American trio of Giovani Lo Celso, Davinson Sanchez and Cristian Romero are finally available for selection, having returned to the UK on Saturday.

We expect club captain Hugo Lloris to take up his usual spot between the sticks, replacing Pierluigi Gollini from midweek, whilst it could be an entirely different back four, with Japhet Tanganga absent through suspension.

Sergio Reguilon and Emerson should come in for both Ben Davies and Matt Doherty - the 29-year-old struggled against Rennes - on the flanks, whilst the aforementioned central defensive duo of Sanchez and Romero could well be thrown straight in, given the club's threadbare options in the role.

In midfield, Tanguy Ndombele should keep his place after making an impressive statement on his first start of the season in France and he could be joined by Pierre-Emile Hojbjerg and Dele Alli in the engine room, meaning there is no place for Oliver Skipp.

Should Son return, then he may well have to be joined by summer signing Bryan Gil, whilst Harry Kane will undoubtedly lead the line.

Predicted Spurs XI vs Chelsea (4-2-3-1): Lloris; Reguilon, Romero, Sanchez, Emerson; Hojbjerg, Ndombele, Alli; Son, Gil, Kane.

AND in other news, 0 dribbles, 0 key passes: £14.4m-rated Spurs passenger badly let Nuno down once again vs Rennes...