Ryan Mason will take charge of his first game as Tottenham Hotspur boss tonight in what could be a crucial week for the club's fortunes.

The north London side welcome Southampton in the Premier League knowing that a win would put them closer towards top-four contention, leapfrogging Liverpool in the process.

And then there's the small matter of the Carabao Cup final on Sunday afternoon, too.

The 29-year-old may want to stamp down his authority and make this side his own whilst he's in temporary control until the end of the campaign and as such, we may well see plenty of changes from Jose Mourinho's recent choices.

So, here's our predicted XI for the first game of the Mason era, as well as the latest team and injury news ahead of kick-off...

predicted-spurs-xi-vs-southampton-team-injury-news-ryan-mason

Mason could be tempted into wholesale changes, especially with one eye on Sunday - a chance to clinch Spurs' first trophy since 2008.

Club captain Hugo Lloris is expected to remain between the sticks, whilst there may even only be a slight alteration to the backline. We expected Spurs to line up in a 4-2-3-1 of sorts, something the 29-year-old has utilised in the academy system.

It would see Sergio Reguilon, Joe Rodon and Toby Alderweireld keep their places, with 27-year-old Eric Dier and the £18m-rated Serge Aurier two casualties.

Young versatile defender Japhet Tanganga could be in line for a recall to the XI after being unfairly axed for the Manchester United and Everton games.

In midfield, it would be a bold call to snub Pierre-Emile Hojbjerg, so he should continue as the engine room enforcer but instead of either one of Spurs' French duo, Moussa Sissoko and Tanguy Ndombele, we may well see a return for Harry Winks, especially as he's someone that has played with Mason before.

Mourinho had snubbed Gareth Bale in recent weeks and he's surely now in line for a boost, along with Dele Alli, who has only played 232 league minutes all campaign. The pair will welcome the change in the dugout and it would not be a shock to see them both start here tonight.

Even more so in the absence of leading talisman Harry Kane.

The Evening Standard have ruled the 27-year-old goalscorer out of this clash as he's yet to train this week. He's also a major doubt for Sunday, too.

[snack-amp-story url=https://www.footballfancast.com/web-stories/read-the-latest-spurs-news-transfer-rumours-and-recent-gossip" title="Read this week's Spurs news, latest transfer rumours and more!]

Mason could push Heung-min Son upfront as he has the work rate to tire defences and run them ragged, it would allow Bale to start in his preferred right-wing spot.

Lucas Moura could then start on the other flank, with Alli through the middle.

In total, that would make five changes.

AND in other news, Spurs could find their next Pochettinio in 45 y/o gem who WOWED Guardiola...