Antonio Conte's Tottenham Hotspur side face Liverpool in Saturday night's 19:45 kick-off, with the result potentially having huge implications on both the Premier League title race and the fight to secure Champions League football next season.
Indeed, with Spurs currently sitting two points behind Arsenal - who play relegation-threatened Leeds United on Sunday - in fourth, the Italian will be well aware that nothing but victory at Anfield will do if his side are to keep the pressure well and truly on their north London rivals.
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Meanwhile, Jurgen Klopp's men currently trail league-leaders Manchester City by a single point, with the German undoubtedly hoping to secure all three points - and subsequently top spot - against Spurs ahead of City's fixture against Newcastle United tomorrow afternoon.
As such, with no room for error for either side, both managers simply must get their team selections spot-on if they are to give their respective clubs the best chance of victory at Anfield, with some big calls needing to be made in each camp.
Will Conte make any changes to the team which lined up in the 3-1 win over Leicester City last weekend? Here's how we at Football FanCast think the Tottenham XI could look against Liverpool, along with the latest team and injury news...
With Conte revealing in his pre-match press conference that Sergio Reguilon will be unavailable for selection tonight, we predict that the 52-year-old will make two changes to the side which started the victory over the Foxes last week.
The back four remains unchanged, with Hugo Lloris starting between the Tottenham sticks, and Ben Davies, Eric Dier and Cristian Romero making up the Italian's three-man backline.
There could be a change at left wing-back, with Ryan Sessegnon dropping to the bench and the "really special" Steven Bergwijn - in the words of Nathan Clark - being handed a rare start in a position for which he appears extremely well-suited, while Emerson Royal retains his place on the right.
In the middle of the park, Pierre-Emile Hojbjerg and Rodrigo Bentancur once again get the nod, while Son Heung-min is joined by the incoming Dejan Kulusevski in the two behind the centre-forward. The £82k-per-week Lucas Moura -who has been branded "awful" byDamian Spellman - misses out this time, while Harry Kane starts up top.
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