After winning their opening four games in Group B, the Hammers are already mathematically assured of a place in the knockout stages, and, with the Irons needing just one more point to seal first place in the group, the Scottish manager looks set to rotate his side after the 2-0 win against Bournemouth on Monday night.
Alphonse Areola will likely continue as West Ham’s starting goalkeeper in Europe, so he replaces Lukasz Fabianski in between the sticks.
It is all change in defence, as Vladimir Coufal and Emerson Palmieri replace Ben Johnson and Aaron Cresswell at full-back in order to get some much-needed minutes under their belts.
There is big news at centre-back as summer signing Nayef Aguerd could be fit to make his first competitive appearance for the club after missing the opening months of the season through injury, and he should partner academy sensation Jamal Baptiste in the heart of the Hammers’ defence.
In midfield, Declan Rice keeps his place in order to provide some security and experience in an otherwise youthful side, and he partners fellow academy graduate Conor Coventry after his impressive displays on loan at MK Dons last season.
After scoring on Monday night, Said Benrahma keeps his place in the attack in the hope that he can build some confidence, while Manuel Lanzini replaces Flynn Downes in attacking midfield and Pablo Fornals comes in for the “unbelievable” Jarrod Bowen on the right, with the Englishman rested ahead of Manchester United on Sunday.
Finally, Michail Antonio replaces Gianluca Scamacca in attack, with the Jamaican no doubt looking to add to his Hammers goal tally after a disappointing start to the new campaign – which has returned just four goals.